Fetal Bovine Serum, Brazil, Heat Inactivated, 500 ml

Heat-inactivated fetal bovine serum is a type of fetal bovine serum that has been treated to inactivate complement proteins. This process involves heating the serum to 56°C for 30 minutes.

Characteristics:

• Inactivation of Complement Proteins: The primary purpose of heat inactivation is to destroy complement proteins, which are part of the immune system and can interfere with cell culture experiments.
  
• Preservation of Growth Factors: Proper heat inactivation should not affect the growth-promoting factors in the serum, ensuring that it still supports cell growth and proliferation.
  
• Quality Standards: Heat inactivated FBS maintains robust quality standards, including low levels of endotoxins and hemoglobin.
  

Applications:

• Immunological Studies: FBS is particularly suited for immunological work where complement proteins might interfere with the binding of antibodies to antigens.
  
• Cell Culture: It is used in cell culture experiments to avoid unwanted interactions between complement proteins and cells, ensuring more accurate results.
  
• Consistency in Experiments: Some researchers use HI FBS to maintain consistency across experiments, especially in labs where heat inactivation has been a standard practice.